What AlphaFold Means for Structural Bioinformatics

WHAT IS STRUCTURAL BIOINFORMATICS?

Source

INTRODUCING THE PROTEIN FOLDING PROBLEM

INTRODUCING CASP

  • The High Accuracy Modeling category is concerned with domains where the majority of submitted models are sufficiently accurate for detailed analysis.
  • The Topology category is concerned with the ability of methods to predict contacts and interresidual distances.
  • The Refinement category is concerned with the analysis of success improving the accuracy of refined models from the initial submissions.
  • The Assembly category is concerned with the assessment of how well methods can predict various interactions.
  • The Accuracy Estimation category is concerned with the ability to provide useful estimates for the overall accuracy of models at the domain and residue level.
  • The Data Assisted category is concerned with how much the accuracy of models is improved by adding sparse data.
  • The Biological Relevance category is concerned with the answers to biological questions that the models provide.

WHAT IS ALPHAFOLD?

Source

HOW DOES ALPHAFOLD WORK?

The architecture of the AlphaFold system [ Source ]

HOW DOES ALPHAFOLD2 WORK?

The attention-based neural network approach can be compared to assembling a puzzle, local chunks are firstly pieced together then fit to form a whole [ Source ]

WHAT ABOUT STRUCTURAL BIOINFORMATICS?

“Structural bioinformatics main objectives are the creation of new methods to deal with biological macromolecules data to solve problems in biology and generate new knowledge.”

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Ammielle WB

Ammielle WB

computational biology & biological computing. ammiellewb.com