Build a Synthetic Biological Circuit at Home

WHAT ARE SYNTHETIC BIOLOGICAL CIRCUITS?

Synthetic biological circuits can allow us to better understand and engineer cells by altering cellular functions, inducing responses to environmental conditions, or influencing cellular development.

A BRIEF OVERVIEW OF GENETICS

A simple diagram of the control process of a GRN I made, inspired by https://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Gene_Regulatory_Network_2.jpg/720px-Gene_Regulatory_Network_2.jpg
  1. Each node in the graph can either be on or off (like 1 and 0 in a binary system!)
  2. If the gene is on, it is expressed. If inputs and outputs are off, they’re present.
  3. The new state of a node is a Boolean function of the prior states of the nodes with arrows pointing towards it.
https://ars.els-cdn.com/content/image/1-s2.0-S200103701930460X-gr1.jpg

A BRIEF OVERVIEW OF LOGIC CIRCUITS

A logic gate is a simple circuit that compares one or more inputs, hence producing a single, outgoing output.

TOOLS FOR SYNTHETIC BIOLOGICAL CIRCUITS

Synthetic biologists will use many tools to computationally simulate synthetic and natural biological circuits.

APPLICATIONS AND RECENT DEVELOPMENTS

Cells could someday react to signal toxic surroundings and react by activating pathways to degrade the present toxins. Thanks to synthetic biological circuits, biological computers might sense inflammatory signals in the body and consequently, produce and release a specific treatment.

FUTURE OF SYNTHETIC BIOLOGICAL CIRCUITS

Synthetic biological circuits have been proven fruitful for metabolic engineering and synthetic biology, successfully producing pharmaceuticals and biofuels. As our knowledge of natural genetic circuitry grows and our understanding of , entire algorithms from control theory could someday be applied

A toolbox of circuitry pieces to create pathways for effective feedback systems?

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